Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Empathy02:34

Empathy

9.0K
Some researchers suggest that altruism operates on empathy. Empathy is the capacity to understand another person’s perspective, to feel what he or she feels. An empathetic person makes an emotional connection with others and feels compelled to help (Batson, 1991). Empathy can be expressed in several ways, including cognitive, affective, and motor. 
9.0K
Cognitive Development During Adolescence01:18

Cognitive Development During Adolescence

976
During adolescence, individuals experience significant cognitive development that enhances their understanding of others' emotions and thoughts, known as cognitive empathy. This period is marked by an increased ability to adapt to others' perspectives and a more nuanced understanding of others' mental states, a skill that is foundational for social problem-solving and conflict avoidance. The development of cognitive empathy relies heavily on the theory of mind — the...
976
Prosopagnosia01:24

Prosopagnosia

1.2K
Prosopagnosia, also known as face blindness, is the inability to recognize faces. In severe cases, individuals with prosopagnosia may not recognize close family members, including parents and spouses, by their faces. For instance, someone with prosopagnosia might walk past their child in a crowd, only realizing their mistake upon noticing their child's distinctive backpack or favorite jacket. Prosopagnosia specifically impairs facial recognition, while the recognition of other objects or...
1.2K
Association Areas of the Cortex01:21

Association Areas of the Cortex

10.1K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
10.1K
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

1.5K
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
1.5K
Personality Disorders: Paranoid and Schizoid01:22

Personality Disorders: Paranoid and Schizoid

1.2K
Personality disorders represent enduring cognition, affect, and behavior patterns that significantly deviate from societal norms. These maladaptive traits often lead to difficulties in various domains, including interpersonal relationships, occupational settings, and overall psychological well-being. Paranoid personality disorder and schizoid personality disorder are two distinct conditions marked by odd or eccentric behavior.
Paranoid Personality Disorder
Paranoid personality disorder is...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Music as a scientific metaphor for mind and brain.

Neuroscience and biobehavioral reviews·2026
Same author

Correction: The role of brain health and resilience in reshaping trajectories of late-life neuropsychiatric disorders.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same author

Evaluation of perception towards brain health in Nigeria: Results from a nationwide awareness survey.

Journal of public health in Africa·2026
Same author

Sociodemographic variables as predictors of antidepressant treatment outcome in major depressive disorder.

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)·2026
Same author

Association of apolipoprotein E variants on Alzheimer's disease in Latin America: A systematic review and meta-analysis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Plasma ATN biomarkers across the alzheimer's disease continuum in a Chilean community- and clinic-based cohort.

Alzheimer's research & therapy·2026

Related Experiment Video

Updated: Apr 21, 2026

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
13:08

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Published on: December 2, 2015

8.1K

Primary empathy deficits in frontotemporal dementia.

Sandra Baez1, Facundo Manes2, David Huepe3

  • 1Institute of Cognitive Neurology (INECO) & Institute of Neuroscience, Favaloro University Buenos Aires, Argentina ; UDP-INECO Foundation Core on Neuroscience (UIFCoN), Diego Portales University Santiago, Chile ; National Scientific and Technical Research Council (CONICET) Buenos Aires, Argentina.

Frontiers in Aging Neuroscience
|October 28, 2014
PubMed
Summary

Behavioral variant frontotemporal dementia (bvFTD) significantly impairs empathy. Empathic concern appears to be a primary deficit in bvFTD, distinct from executive function or social cognition impairments.

Keywords:
behavioral variant of frontotemporal dementiaempathic concernempathyexecutive functionsmoral judgmentsocial cognition

More Related Videos

The Dig Task: A Simple Scent Discrimination Reveals Deficits Following Frontal Brain Damage
11:16

The Dig Task: A Simple Scent Discrimination Reveals Deficits Following Frontal Brain Damage

Published on: January 4, 2013

15.9K
Conscious and Non-conscious Representations of Emotional Faces in Asperger's Syndrome
08:31

Conscious and Non-conscious Representations of Emotional Faces in Asperger's Syndrome

Published on: July 31, 2016

13.1K

Related Experiment Videos

Last Updated: Apr 21, 2026

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
13:08

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Published on: December 2, 2015

8.1K
The Dig Task: A Simple Scent Discrimination Reveals Deficits Following Frontal Brain Damage
11:16

The Dig Task: A Simple Scent Discrimination Reveals Deficits Following Frontal Brain Damage

Published on: January 4, 2013

15.9K
Conscious and Non-conscious Representations of Emotional Faces in Asperger's Syndrome
08:31

Conscious and Non-conscious Representations of Emotional Faces in Asperger's Syndrome

Published on: July 31, 2016

13.1K

Area of Science:

  • Neuroscience
  • Psychology
  • Clinical Neurology

Background:

  • Loss of empathy is a core symptom of behavioral variant frontotemporal dementia (bvFTD).
  • Empathy deficits significantly impact social functioning in bvFTD patients.
  • Experimental investigation of empathy in bvFTD using validated paradigms is limited.

Purpose of the Study:

  • To assess affective, cognitive, and moral empathy components in early/mild stage bvFTD patients.
  • To determine if empathy loss in bvFTD is a primary deficit or secondary to executive function (EF) and social cognition impairments.
  • To explore the relationship between empathy, EF, emotion recognition, and theory of mind (ToM) in bvFTD.

Main Methods:

  • Thirty-seven bvFTD patients and 30 healthy controls were assessed.
  • A task involving perception of intentional and accidental harm was administered.
  • Participants completed assessments for emotion recognition, ToM, social norms, and EF.

Main Results:

  • bvFTD patients showed deficits across affective, cognitive, and moral empathy domains.
  • Empathic concern was identified as the only empathy aspect primarily affected and independent of EF or other social cognition deficits.
  • Cognitive and moral empathy deficits were linked to EF, emotion recognition, and ToM impairments.

Conclusions:

  • Empathic concern represents a primary deficit in bvFTD, distinct from executive function and social cognition.
  • Cognitive and moral empathy deficits in bvFTD appear secondary to impairments in executive functions, emotion recognition, and theory of mind.
  • Real-life social scenario tasks are more sensitive for assessing bvFTD, offering crucial theoretical and clinical insights.