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Updated: Apr 21, 2026

Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells
Published on: March 23, 2022
Ontogeny of intestinal epithelial innate immune responses
Mathias W Hornef1, Marcus Fulde2
1Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School , Hannover , Germany ; Institute of Medical Microbiology, RWTH University , Aachen , Germany.
Abstract:
Emerging evidence indicates that processes during postnatal development might significantly influence the establishment of mucosal host-microbial homeostasis. Developmental and adaptive immunological processes but also environmental and microbial exposure early after birth might thus affect disease susceptibility and health during adult life. The present review aims at summarizing the current understanding of the intestinal epithelial innate immune system and its developmental and adaptive changes after birth.
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