Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

1.7K
Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
1.7K
Stem Cell Niche01:26

Stem Cell Niche

4.9K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
4.9K
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

2.6K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.6K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.4K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.4K
Tissue Transplantation01:24

Tissue Transplantation

1.4K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.4K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

4.5K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel female murine alveolar osteoblasts responsive to hormones and mechanical forces.

BoneĀ·2026
Same author

Bone Multicellular Unit on a Chip (BMU-Chip) Subjected to Cyclic Mechanical Loading.

ACS biomaterials science & engineeringĀ·2026
Same author

Leveraging Longitudinal Data to Improve BrainChart Calibration for Small Study Sample Sizes.

Human brain mappingĀ·2026
Same author

GsĪ± Deficiency in Osteocytes Alters Craniofacial Growth and Enamel Mineralisation.

Orthodontics & craniofacial researchĀ·2025
Same author

Bystander Effects in Osteoblasts and Osteoclasts: Comparison Between X- and Proton-Irradiation.

International journal of particle therapyĀ·2025
Same author

Heterogeneous, temporally consistent, and plastic brain development after preterm birth.

Nature communicationsĀ·2025

Related Experiment Video

Updated: Apr 21, 2026

Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform
11:08

Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform

Published on: January 13, 2019

14.0K

Osteocyte biology and space flight.

Paola Divieti Pajevic1, Jordan M Spatz1, Jenna Garr1

  • 1Endocrine Unit, Mass General Hospital, Harvard Medical School, Boston, MA, USA.

Current Biotechnology
|October 28, 2014
PubMed
Summary

Osteocytes regulate bone homeostasis by sensing mechanical forces and hormonal signals. New research explores how these bone cells perceive mechanical stimuli for better understanding of skeletal mechano transduction.

More Related Videos

Culturing Lymphocytes in Simulated Microgravity Using a Rotary Cell Culture System
09:28

Culturing Lymphocytes in Simulated Microgravity Using a Rotary Cell Culture System

Published on: August 25, 2022

3.3K
Assessment of Global Ocular Structure Following Spaceflight Using a Micro-Computed Tomography Micro-CT Imaging Method
09:11

Assessment of Global Ocular Structure Following Spaceflight Using a Micro-Computed Tomography Micro-CT Imaging Method

Published on: October 27, 2020

5.3K

Related Experiment Videos

Last Updated: Apr 21, 2026

Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform
11:08

Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform

Published on: January 13, 2019

14.0K
Culturing Lymphocytes in Simulated Microgravity Using a Rotary Cell Culture System
09:28

Culturing Lymphocytes in Simulated Microgravity Using a Rotary Cell Culture System

Published on: August 25, 2022

3.3K
Assessment of Global Ocular Structure Following Spaceflight Using a Micro-Computed Tomography Micro-CT Imaging Method
09:11

Assessment of Global Ocular Structure Following Spaceflight Using a Micro-Computed Tomography Micro-CT Imaging Method

Published on: October 27, 2020

5.3K

Area of Science:

  • Bone Biology
  • Skeletal Physiology
  • Cellular Mechanotransduction

Background:

  • Osteocytes are crucial regulators of bone homeostasis and mechanical sensing.
  • These cells are embedded within the bone matrix, mediating responses to mechanical forces and hormones.
  • Osteocytes coordinate osteoblast and osteoclast activity via secreted factors like Sclerostin and RANKL.

Purpose of the Study:

  • To highlight novel investigations into osteocyte function.
  • To discuss the significance of osteocytes in skeletal mechano transduction.
  • To explore the mechanisms by which osteocytes perceive and respond to mechanical stimuli.

Main Methods:

  • Utilizing novel in vitro models to study osteocytes.
  • Investigating osteocyte behavior under microgravity conditions.
  • Analyzing molecular and cellular mechanisms of mechano transduction.

Main Results:

  • Significant expansion in understanding osteocyte roles in skeletal homeostasis over the last decade.
  • Identification of osteocytes as key regulators of bone homeostasis and mechanosensation.
  • Osteocytes translate mechanical forces into biological responses and coordinate bone remodeling.

Conclusions:

  • Osteocyte mechanotransduction mechanisms are an active area of research.
  • Novel models and microgravity studies offer insights into osteocyte mechano transduction.
  • Further understanding of osteocytes is vital for skeletal health research.