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Updated: Apr 21, 2026

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
Published on: February 15, 2016
Total synthesis of tricladins A and B and identification of their absolute configuration
He Zhao1, Zhongping Huang, Wen Chen
1AMRI , 26 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098, United States.
Abstract:
A concise synthesis of both (S)- and (R)-enantiomers of tricladins A and B from l-Boc alanine was achieved. The diastereomeric intermediates were separated by chiral column chromatography, and the absolute configuration of the 2-position was assigned by observed NOE interactions with the known stereogenic center at the 5-position. By comparison of all synthesized final enantiomers with the corresponding natural products, we concluded that the natural tricladins A and B must have the (R)-configuration.
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