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Asymmetric intrauterine growth restriction is a risk factor for respiratory inhibition after crying in infants

Hideki Minowa1, Aya Mima1, Yuka Ikeda1

  • 1a Department of Neonatal Intensive Care Unit , Nara Prefectural NARA Hospital , Nara , Japan.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|October 28, 2014
PubMed

Insights

Asymmetric intrauterine growth restriction (IUGR) is linked to increased risk of respiratory inhibition after crying (RIAC) and feeding hypoxemia in infants. Early screening for RIAC in these infants is recommended.

Area of Science:

  • Neonatal Medicine
  • Pediatric Respiratory Health
  • Fetal Development

Background:

  • Intrauterine growth restriction (IUGR) affects fetal development and can have long-term health implications.
  • Respiratory complications in newborns require careful monitoring and understanding of underlying causes.

Purpose of the Study:

  • To investigate the correlation between different types of intrauterine growth restriction (IUGR) and the occurrence of respiratory inhibition after crying (RIAC) and feeding hypoxemia.
  • To identify specific IUGR patterns that may predispose infants to respiratory issues.

Main Methods:

  • A cohort of 1248 infants with gestational age ≥36 weeks was screened for RIAC using cranial ultrasound, SpO2 monitoring, and polygraphy.
  • Infants were categorized into symmetric IUGR, asymmetric IUGR, and control groups.
  • Perinatal factors, RIAC incidence, and feeding hypoxemia were compared across the groups.

Main Results:

  • Asymmetric IUGR was observed in 143 infants, symmetric IUGR in 26, and 1079 were controls.
  • RIAC occurred in 6.9% of asymmetric IUGR infants versus 3.4% of controls.
  • Feeding hypoxemia occurred in 10.5% of asymmetric IUGR infants versus 4.8% of controls.
  • Symmetric IUGR infants showed no instances of RIAC or feeding hypoxemia.

Conclusions:

  • Asymmetric IUGR is identified as a significant risk factor for both RIAC and feeding hypoxemia.
  • Infants diagnosed with asymmetric IUGR warrant aggressive screening for RIAC.
  • Understanding these associations can guide clinical management and improve outcomes for at-risk newborns.
Abstract

Keywords:
Cranial ultrasoundSpO2 monitoringhypoxemiapolygraphysudden infant death syndrome

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