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Factors associated with beta-cell dysfunction in type 2 diabetes: the BETADECLINE study
Giuseppina T Russo1, Carlo Bruno Giorda2, Stefania Cercone3
1Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Plos One
|October 28, 2014
Summary
Beta-cell dysfunction, a key factor in type 2 diabetes, was more prevalent in men and patients using secretagogue medications. Further research will identify predictors of beta-cell failure in these patients.
Area of Science:
- Endocrinology
- Metabolic Diseases
- Diabetes Research
Background:
- Beta-cell dysfunction is an early and variable event in type 2 diabetes.
- Identifying clinical predictors of beta-cell dysfunction progression is crucial for managing type 2 diabetes.
Purpose of the Study:
- To report baseline data from the Italian BetaDecline study.
- To investigate clinical predictors of beta-cell dysfunction in type 2 diabetes outpatients.
Main Methods:
- Collected clinical, lifestyle, and laboratory data from 507 type 2 diabetic outpatients.
- Assessed beta-cell dysfunction using the proinsulin/insulin ratio (P/I).
Main Results:
- Higher P/I ratios were associated with male sex and secretagogue drug use.
- Subjects with higher P/I ratios showed higher HbA1c and fasting glucose.
- Lower BMI, cholesterol levels, CRP, HOMA-B, and HOMA-IR were observed with increasing P/I ratio quartiles.
Conclusions:
- Higher P/I ratios, indicating beta-cell dysfunction, were more frequent in men and patients on secretagogue drugs at baseline.
- The BetaDecline cohort follow-up will identify clinical predictors of beta-cell failure.
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