Related Experiment Video
Updated: Apr 21, 2026

09:04
Measurement of T Cell Alloreactivity Using Imaging Flow Cytometry
Published on: April 19, 2017
17.0K
Transplantation: molecular phenotyping of T-cell-mediated rejection
Anita S Chong1, David L Perkins2
1Department of Surgery, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA.
Nature Reviews. Nephrology
|October 29, 2014
Abstract:
A new study has reported a molecular signature of T-cell-mediated rejection in human kidney transplant biopsy samples that is enriched for effector T cells, interferon-γ and macrophages. Inhibitors of T-cell activation, such as CTLA4 and PDL1, were also prominent, raising the possibility that these immunological constrains could be harnessed by therapies for treating rejection.
Related Concept Videos
Cell-mediated Immune Responses
63.9K
Overview
63.9K
Tissue Transplantation
1.4K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.4K
T Cell Activation and Clonal Selection
13.5K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
13.5K

