Related Experiment Video
Updated: Apr 21, 2026
07:42
Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients
Published on: December 16, 2022
3.1K
Validity of EQ-5D-5L in stroke
Dominik Golicki1, Maciej Niewada, Julia Buczek
1Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Banacha 1b St, 02-097, Warsaw, Poland, dominik.golicki@gmail.com.
Summary
The EQ-5D-5L (EuroQol 5-Dimensions 5-Levels) measure shows improved validity and discriminatory power for assessing health outcomes in acute stroke patients compared to the EQ-5D-3L (3-Levels) version.
Area of Science:
- Health outcomes research
- Psychometric validation
- Neurology
Background:
- The EQ-5D-3L (3-Levels) is a widely used generic health outcome measure.
- Assessing health status in acute stroke patients requires sensitive and valid instruments.
- The EQ-5D-5L (5-Levels) offers a more granular approach to health state description.
Purpose of the Study:
- To evaluate the validity of the EQ-5D-5L in acute stroke patients.
- To compare the psychometric performance of EQ-5D-5L against the EQ-5D-3L.
Main Methods:
- A cross-sectional study involving 408 patients hospitalized with acute stroke.
- Comparison of EQ-5D-5L and EQ-5D-3L on feasibility, unique health states, ceiling effect, and discriminatory power.
- Assessment of construct validity using known-groups and convergent validity with established stroke outcome measures (mRS, BI, VAS).
Main Results:
- EQ-5D-5L captured a lower proportion of patients reporting 'no problems' (5.6%) compared to EQ-5D-3L (6.1%), indicating better sensitivity.
- Significant improvements in discriminatory power were observed for the pain/discomfort and anxiety/depression dimensions with EQ-5D-5L.
- Known-groups validity was confirmed, with lower utilities associated with female sex, higher mRS, lower BI/VAS, specific stroke types, and proxy respondents. EQ-5D-5L showed improved or equivalent convergence with other measures.
Conclusions:
- The EQ-5D-5L is a valid generic health outcome measure for acute stroke patients.
- EQ-5D-5L demonstrates psychometric advantages over EQ-5D-3L in this population, particularly in capturing nuanced health states.
Related Concept Videos
01:22Cardiac Output II: Effect of Stroke Volume on Cardiac Output
4.6K
Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
4.6K
01:15Ischemic Stroke l: Introduction
9
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
9