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Sequences are fundamental mathematical objects consisting of ordered lists of numbers that follow a specific rule or pattern. Sequences are critical in various mathematical concepts, including calculus, series, and number theory. They can model real-world phenomena such as population growth, financial investments, and physical processes like the diminishing height of a bouncing ball.Each number in a sequence is referred to as a term. Typically, the terms are denoted as a1, a2, a3,…, where...
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An ideal Y-Y transformer, grounded through neutral impedances, displays per-unit sequence networks akin to those of a single-phase ideal transformer when subjected to balanced positive- or negative-sequence currents. These currents do not produce neutral currents, and their associated voltage drops.
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Genome3D: exploiting structure to help users understand their sequences.

Tony E Lewis1, Ian Sillitoe2, Antonina Andreeva3

  • 1Institute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, London, WC1E 6BT, UK.

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Summary
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Genome3D is an enhanced resource providing protein domain annotations and structural models. It now covers more organisms and sequences, with improved search and analysis tools for structural biology research.

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Area of Science:

  • Structural Biology
  • Bioinformatics
  • Genomics

Background:

  • Genome3D is a collaborative resource for predicted domain annotations and structural models.
  • Previous versions focused on limited model organisms and lacked advanced search functionalities.

Purpose of the Study:

  • To substantially extend and improve the Genome3D resource.
  • To enhance sequence coverage, search capabilities, and structural model analysis tools.

Main Methods:

  • Annotated representatives from Pfam families for broader sequence coverage.
  • Integrated VIVACE resource and expanded data from 3 to 10 model organisms.
  • Updated SCOP/CATH mapping and enhanced structural model superposition tools.

Main Results:

  • Increased coverage of diverse protein sequences through Pfam annotations.
  • Improved website functionality with a fast sequence search.
  • Expanded dataset including VIVACE and data from 10 model organisms.
  • Enhanced structural analysis via updated superposition tools.

Conclusions:

  • The improved Genome3D resource offers more comprehensive domain annotations and structural models.
  • Enhanced search and analysis tools facilitate structural biology research.
  • Genome3D serves as a valuable tool for investigating protein sequence and structural similarities.