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Related Experiment Video

Updated: Apr 21, 2026

Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics

Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics

Published on: June 17, 2012

CATH: comprehensive structural and functional annotations for genome sequences.

Ian Sillitoe¹, Tony E Lewis², Alison Cuff²

¹Institute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, WC1E 6BT, UK i.sillitoe@ucl.ac.uk.

Nucleic Acids Research

|October 29, 2014

Summary

This summary is machine-generated.

The CATH-Gene3D database (version 4.0) now offers enhanced protein domain structure annotations and predictions. Key updates include improved functional family predictions and new datasets for benchmarking.

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High-throughput Identification of Gene Regulatory Sequences Using Next-generation Sequencing of Circular Chromosome Conformation Capture 4C-seq

High-throughput Identification of Gene Regulatory Sequences Using Next-generation Sequencing of Circular Chromosome Conformation Capture 4C-seq

Published on: October 5, 2018

Area of Science:

Structural bioinformatics
Computational biology
Protein domain analysis

Background:

The CATH-Gene3D database classifies protein domain structures.
Previous versions have provided valuable annotations and predictions.
Continuous updates are essential for advancing structural bioinformatics.

Purpose of the Study:

To report major developments in the CATH-Gene3D database since its last publication.
To highlight improvements in functional family (FunFams) prediction accuracy.
To introduce new resources for the scientific community, including CATH-B and CATH-40.

Main Methods:

Database curation and annotation of protein domain structures.
Development and refinement of algorithms for predicting functional families (FunFams).
Creation of non-redundant datasets (CATH-40) for homology benchmarking.

Main Results:

CATH-Gene3D version 4.0 includes over 235,000 domain structures and 25 million predictions.
Significant improvements in the predictive power of functional families (FunFams).
Release of 'current' putative domain assignments (CATH-B) and a non-redundant CATH domain set (CATH-40).

Conclusions:

The updated CATH-Gene3D database offers enhanced resources for protein structure classification and analysis.
Improvements in FunFams and new datasets facilitate more accurate protein research and homology benchmarking.
Ongoing development ensures CATH-Gene3D remains a vital tool in structural bioinformatics.