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Nattokinase: production and application.

Fatemeh Dabbagh¹, Manica Negahdaripour, Aydin Berenjian

¹Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Applied Microbiology and Biotechnology

|October 29, 2014

Summary

Nattokinase, an enzyme from Bacillus subtilis natto, exhibits direct fibrinolytic activity, making it a promising oral thrombolytic agent. Its safety, ease of production, and diverse applications establish it as a valuable nutraceutical.

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Area of Science:

Biotechnology
Enzymology
Pharmacology

Background:

Nattokinase (NK) is an extracellular enzyme from Bacillus subtilis natto.
It possesses direct fibrinolytic activity, crucial for thrombolytic therapy.
NK is stable in the gastrointestinal tract, enabling oral administration.

Purpose of the Study:

To provide a concise description of Nattokinase.
To summarize biotechnological methods for NK production, recovery, and purification.
To discuss NK's applications and future prospects.

Main Methods:

Review of literature on Nattokinase.
Summary of biotechnological production strategies.
Compilation of reported applications and research findings.

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Main Results:

Nattokinase demonstrates significant fibrinolytic properties.
It is recognized as a safe and easily produced nutraceutical.
Potential therapeutic applications include hypertension, Alzheimer's disease, and vitreoretinal disorders.

Conclusions:

Nattokinase is a valuable enzyme with direct fibrinolytic activity.
Its stability and production efficiency support its use as a dietary supplement.
Further research into its therapeutic potential is warranted.