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Updated: Apr 21, 2026
Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
Published on: August 1, 2018
Correlation of HER-2/Neu protein expression and HER2 gene amplification with clinical morphological parameters of
D S Kobyakov1, A M Avdalyan, I P Bobrov
1Altai Affiliated Branch of N. N. Blokhin Russian Cancer Center, Russian Academy of Medical Sciences, Barnaul, Russia, pathol@soramn.ru.
Abstract:
A total of 218 operation specimens from patients with nonsmall cell lung cancer were examined. The expression of HER-2 protein was studied by the immunohistochemical method, amplification of HER2 gene and centromere part of chromosome 17 (CEP17) - by the in situ chromogenic hybridization method. Moderate correlation (r=0.38, p<0.001) between the immunohistochemical status and HER2 gene amplification was detected. A relationship between TNM clinical morphological parameters and HER-2 protein content and chromosome 17 polysomia (for N parameter), HER-2 protein content, and HER2 gene amplification (for tumor histogenesis) was detected. The content of HER-2 protein and amplification of HER2 and CEP17 correlated with the clinical morphological parameters of patients with nonsmall cell lung cancer.
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