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Very low birthweight bronchopulmonary dysplasia survivors show no substantial association between lung function and

Piia Suursalmi1, Tarja Kopeli, Päivi Korhonen

  • 1Department of Pediatrics, Tampere University Hospital, Tampere, Finland; Tampere Center for Child Health Research, Tampere University Hospital and University of Tampere, Tampere, Finland.

Acta Paediatrica (Oslo, Norway : 1992)
|October 29, 2014
PubMed

Insights

Lung function in school-aged survivors of bronchopulmonary dysplasia (BPD) was assessed. While those with radiographic BPD showed poorer lung function, inflammatory markers had minimal association with lung health outcomes.

Area of Science:

  • Pediatric Pulmonology
  • Neonatology
  • Inflammation Research

Background:

  • Bronchopulmonary dysplasia (BPD) is a chronic lung disease affecting premature infants.
  • The long-term respiratory health and inflammatory status of BPD survivors remain incompletely understood.
  • Evaluating lung function and inflammatory markers in school-aged survivors is crucial for understanding disease sequelae.

Purpose of the Study:

  • To investigate lung function in school-aged very low birthweight (VLBW) survivors.
  • To correlate lung function with inflammatory markers in plasma, exhaled breath condensate, and exhaled air.
  • To compare VLBW children with and without radiographic BPD.

Main Methods:

  • Impulse oscillometry (pre- and post-bronchodilator) was performed on VLBW children with and without radiographic BPD, and term controls.
  • Plasma inflammatory markers (e.g., eosinophilic cationic protein, interleukins, adiponectin) were measured.
  • Exhaled breath condensate (leukotriene B4, 8-isoprostane) and nitric oxide output were analyzed.

Main Results:

  • Abnormal lung function was observed in 12.5% of VLBW children.
  • Highest airway resistance was noted in the radiographic BPD group.
  • Bronchodilator responses were most significant in VLBW children without radiographic BPD.

Conclusions:

  • School-aged VLBW children with radiographic BPD exhibited the poorest lung function.
  • Bronchodilator responsiveness varied between VLBW groups.
  • Detected inflammatory markers showed limited association with lung function in school-aged BPD survivors.
Abstract

Keywords:
AdipokinesBronchopulmonary dysplasiaImpulse oscillometryInflammationLung functionVery low birthweight

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