Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

653
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
653
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

748
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
748
Papillary Dermis01:11

Papillary Dermis

5.7K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
5.7K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

1.1K
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
1.1K
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

899
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
899
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.1K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Review of Post-Inflammatory Pigmentation Changes: Pathophysiology, Diagnosis and Treatment.

Journal of cutaneous medicine and surgery·2026
Same author

The combined diagnostic value of 5-hmC and PRAME immunohistochemistry in melanocytic neoplasms.

Pathology, research and practice·2025
Same author

GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets.

Nature communications·2025
Same author

Effectiveness and safety of secukinumab updosing in patients with moderate to severe plaque psoriasis: data from the PURE registry.

Archives of dermatological research·2024
Same author

GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets.

medRxiv : the preprint server for health sciences·2023
Same author

Metabolic Lipids in Melanoma Enable Rapid Determination of Actionable BRAF-V600E Mutation with Picosecond Infrared Laser Mass Spectrometry in 10 s.

Analytical chemistry·2023

Related Experiment Video

Updated: Apr 21, 2026

Anti-Nuclear Antibody Screening Using HEp-2 Cells
13:01

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

140.2K

Cutaneous polyarteritis nodosa sine nodosa.

Erica Merman, Cheryl Rosen, Danny Ghazarian

    Journal of Cutaneous Medicine and Surgery
    |October 29, 2014
    PubMed
    Summary

    Cutaneous polyarteritis nodosa typically presents with nodules. This case highlights a rare variant primarily featuring livedo reticularis, demonstrating the diverse clinical spectrum of this vasculitis.

    Area of Science:

    • Dermatology
    • Rheumatology
    • Internal Medicine

    Background:

    • Cutaneous polyarteritis nodosa (CPN) is a vasculitis affecting small to medium arteries.
    • CPN commonly manifests as subcutaneous nodules on the lower extremities.
    • Associated features include livedo reticularis, ulcers, and plaques.

    Observation:

    • A 51-year-old woman presented with a distinctive dermatological condition.
    • Her primary symptom was livedo reticularis.
    • Crucially, she lacked the typical nodular component of CPN.

    Findings:

    • The case illustrates an atypical presentation of cutaneous polyarteritis nodosa.
    • Livedo reticularis was the predominant clinical feature.
    • The absence of nodules challenged the conventional diagnostic criteria.

    More Related Videos

    Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay
    08:33

    Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay

    Published on: June 25, 2019

    7.7K
    Granulocyte-dependent Autoantibody-induced Skin Blistering
    12:23

    Granulocyte-dependent Autoantibody-induced Skin Blistering

    Published on: October 12, 2012

    9.9K

    Related Experiment Videos

    Last Updated: Apr 21, 2026

    Anti-Nuclear Antibody Screening Using HEp-2 Cells
    13:01

    Anti-Nuclear Antibody Screening Using HEp-2 Cells

    Published on: June 23, 2014

    140.2K
    Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay
    08:33

    Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay

    Published on: June 25, 2019

    7.7K
    Granulocyte-dependent Autoantibody-induced Skin Blistering
    12:23

    Granulocyte-dependent Autoantibody-induced Skin Blistering

    Published on: October 12, 2012

    9.9K

    Implications:

    • This case expands the understanding of CPN's clinical variability.
    • It underscores the importance of considering CPN in patients with livedo reticularis, even without nodules.
    • Early recognition of atypical presentations is crucial for timely diagnosis and management of vasculitis.