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Updated: Apr 21, 2026

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
Impact of physicochemical environment on the super disintegrant functionality of cross-linked carboxymethyl sodium
Michèle Delalonde1, Raja Fitouri, Emilie Ruiz
1UMR Qualisud, UFR des Sciences Pharmaceutiques et Biologiques, Université Montpellier 1, 15 Avenue Charles Flahault BP 14491, 34093, Montpellier Cedex 5, France, michele.delalonde@univ-montp1.fr.
Abstract:
The aim of this work is to improve the understanding of the physicochemical mechanisms involved in the functionality of cross-linked carboxymethyl sodium starch (CCSS) as a tablet super disintegrant (SD). The behavior and properties of this SD (medium uptake, disintegration times, particle size, and rheology) was investigated in a wetting medium of different physicochemical properties. In particular, the relative permittivity (dielectric constant) of these media was intentionally modified for evaluating its effect on CCSS properties. Results showed different swelling behaviors of CCSS particles according to the relative permittivity of the tested media and allow to propose two underlying mechanisms that explain CCSS functionality. Both the intra-particular swelling and the inter-particular repulsion are affected by the relative permittivity of the media. Finally, disintegration test performed on tablets specially formulated with mannitol (used commonly as an excipient and known to modify relative permittivity) confirmed that the functionality of CCSS and therefore the disintegration of the tablet can be altered according to the mannitol content.
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