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Impaired aortic elasticity and diastolic functions are associated with findings of coronary computed tomographic

Hüseyin Ede1, Mustafa Fatih Erkoç2, Aylin Okur2

  • 1Department of Cardiology, Bozok University School of Medicine, Yozgat, Turkey.

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
|October 29, 2014
PubMed

Insights

Aortic elasticity and diastolic function are linked to coronary artery disease severity. Increased aortic stiffness correlates with higher coronary calcium scores and plaque area, aiding CAD assessment.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Echocardiography

Background:

  • Coronary artery disease (CAD) is a major global health concern.
  • Aortic elasticity and diastolic function are key indicators for CAD assessment.
  • Echocardiography and coronary computed tomography angiography (CCTA) are vital diagnostic tools.

Purpose of the Study:

  • To investigate the association between echocardiographically measured aortic elastic properties and diastolic function with CCTA-derived measures of CAD.
  • To correlate aortic stiffness index (ASI) and aortic distensibility (AD) with coronary calcium score (CACS), epicardial fat volume (EFV), and plaque area.

Main Methods:

  • A prospective study of 106 patients with suspected CAD undergoing CCTA and echocardiography.
  • Calculation of CACS, plaque area, and EFV using CCTA.
  • Measurement of ASI and AD via echocardiography.

Main Results:

  • Patients with any degree of diastolic dysfunction exhibited higher ASI, CACS, plaque area, and EFV.
  • A strong positive correlation was found between increasing ASI, CACS, and total coronary plaque area.
  • A significant, though weaker, correlation existed between ASI and EFV.

Conclusions:

  • Aortic elasticity demonstrates a correlation with CACS and plaque area.
  • Diastolic dysfunction is more prevalent in patients with elevated CACS and EFV.
  • CACS is a stronger indicator of aortic elasticity than EFV.
Abstract

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