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New 19-oxygenated steroid from the South China Sea gorgonian Dichotella gemmacea
Fei Cao1, Hai-Yan Liu, Jie Zhao
1a Key Laboratory of Marine Drugs, The Ministry of Education of China , School of Medicine and Pharmacy, Ocean University of China , 5 Yushan Road, Qingdao 266003 , Shandong , P.R. China.
Abstract:
A new 19-oxygenated steroid, 25-acetate-nebrosteroid K (1), and five known steroids (2-6), along with one known 19-hydroxy steroidal glycoside (7) were obtained from the gorgonian Dichotella gemmacea collected from the South China Sea. The structure and relative configuration of 1 were elucidated by using comprehensive spectroscopic data including NOESY spectra. Compound 1 represents the first example of 19-oxygenated steroid with a 19-oic acid methyl ester group isolated from gorgonians. All of the isolated compounds were evaluated for lethal activity to brine shrimp Artemia salina and cytotoxicity against A549 and HL-60 cell lines. Among them, 1 showed strong lethality towards A. salina.