Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

2.5K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.5K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

6.9K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
6.9K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.4K
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ofirnoflast: a first-in-class NEK7-targeted inhibitor of the NLRP3 inflammasome.

Journal of drug targeting·2025
Same author

Theranostic nanoparticles: Investigation of superparamagnetic iron oxide nanoparticles intrinsically labeled with Zirconium-89 and Actinium-225.

Nuclear medicine and biology·2025
Same author

PET Imaging Expedites Detection of Aberration in the Humanization of an Annexin A1 Targeting Antibody.

Pharmaceuticals (Basel, Switzerland)·2025
Same author

Slip Flow in Hydrophilic Nanopores of Silica Colloidal Crystals.

Langmuir : the ACS journal of surfaces and colloids·2025
Same author

Highly Calibrated Relationship Between Bleomycin Concentrations and Facets of the Active Phase Fibrosis in Classical Mouse Bleomycin Model.

International journal of molecular sciences·2024
Same author

Regulated N-glycosylation controls chaperone function and receptor trafficking.

Science (New York, N.Y.)·2024

Related Experiment Video

Updated: Apr 21, 2026

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

7.4K

Tumor targeting, trifunctional dendritic wedge.

Ramin Dubey1, Swati Kushal, Alexis Mollard

  • 1Department of Pharmacology and Pharmaceutical Sciences, University of Southern California , 1985 Zonal Avenue, PSC B15C, HSC 9121, Los Angeles, California 90089, United States.

Bioconjugate Chemistry
|October 29, 2014
PubMed
Summary
This summary is machine-generated.

We developed a new theranostic agent for solid tumors, combining boron for therapy/imaging, a fluorescent dye, and a targeting ligand. This agent shows rapid accumulation and retention in tumors for potential boron neutron capture therapy applications.

More Related Videos

Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization
09:49

Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization

Published on: December 2, 2013

12.3K
Three-Dimensional 3D Tumor Spheroid Invasion Assay
12:19

Three-Dimensional 3D Tumor Spheroid Invasion Assay

Published on: May 1, 2015

60.8K

Related Experiment Videos

Last Updated: Apr 21, 2026

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

7.4K
Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization
09:49

Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization

Published on: December 2, 2013

12.3K
Three-Dimensional 3D Tumor Spheroid Invasion Assay
12:19

Three-Dimensional 3D Tumor Spheroid Invasion Assay

Published on: May 1, 2015

60.8K

Area of Science:

  • Nanomedicine
  • Molecular Imaging
  • Cancer Therapy

Background:

  • Solid tumors present challenges for targeted therapies.
  • Theranostic agents offer combined diagnostic and therapeutic capabilities.
  • Boron Neutron Capture Therapy (BNCT) requires efficient boron delivery to tumors.

Purpose of the Study:

  • To evaluate a novel trifunctional theranostic agent for solid tumor targeting.
  • To assess the agent's potential for boron neutron capture therapy (BNCT) and magnetic resonance imaging (MRI).
  • To investigate the agent's utility in fluorescent imaging and targeted delivery.

Main Methods:

  • In vitro and in vivo evaluation of the trifunctional agent.
  • Characterization of photophysical properties and cellular uptake.
  • Live animal imaging and intravital microscopy (IVM) in melanoma and adenocarcinoma models.

Main Results:

  • The agent demonstrated efficient tumor targeting and prolonged retention (up to 7 days) in vivo.
  • Rapid accumulation was observed in established solid tumors.
  • Successful combination of boron delivery, fluorescence imaging, and targeting ligand functionality.

Conclusions:

  • The developed macromolecular theranostic agent is suitable for targeted delivery of boron to solid tumors.
  • This agent holds promise for future applications in BNCT and multimodal imaging.
  • The trifunctional design facilitates combined diagnostic and therapeutic strategies for cancer treatment.