Related Experiment Video
Updated: Apr 21, 2026

Author Spotlight: Enhancing the Offspring Health in Rats with Maternal Exercise During Pregnancy
Published on: April 5, 2024
Physical activity during pregnancy and offspring neurodevelopment and IQ in the first 4 years of life
Marlos R Domingues1, Alicia Matijasevich2, Aluísio J D Barros3
1Sports Department, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
Insights
Maternal physical activity during pregnancy is linked to better cognitive development in children. Active mothers
Area of Science:
- Pediatrics
- Neuroscience
- Public Health
Background:
- Maternal physical activity during pregnancy is a modifiable factor with potential implications for offspring neurodevelopment.
- Understanding the relationship between maternal exercise and child cognitive outcomes is crucial for public health recommendations.
- Existing research suggests a link, but further investigation is needed to clarify the extent and timing of these effects.
Purpose of the Study:
- To investigate the association between maternal physical activity during pregnancy and neurodevelopmental outcomes in children.
- To evaluate the impact of maternal exercise on children's cognitive abilities, specifically IQ and overall development.
- To determine if maternal physical activity influences neurodevelopment from infancy through early childhood.
Main Methods:
- A birth cohort study followed children from birth to 48 months of age.
- Maternal physical activity was assessed retrospectively, and neurodevelopment was evaluated using the Battelle's Development Inventory and IQ using the Weschler's Intelligence Scale.
- Statistical analyses controlled for potential confounding factors including socioeconomic status, maternal characteristics, and neonatal factors.
Main Results:
- Children born to mothers who were physically active during pregnancy showed higher Battelle's scores at 12 and 24 months.
- A crude analysis indicated a slight increase in IQ at 48 months among children of active mothers.
- After adjusting for confounders, a positive association was observed between maternal physical activity and neurodevelopment at 12 months, but not at 48 months.
Conclusions:
- Maternal physical activity during pregnancy does not appear to negatively impact children's neurodevelopment.
- Offspring of physically active mothers demonstrated enhanced cognitive performance at 12 months of age.
- The findings suggest a potential benefit of maternal exercise on early childhood neurodevelopment, particularly in the first year of life.
Background:
Maternal physical activity during pregnancy could alter offspring's IQ and neurodevelopment in childhood.
Methods:
Children belonging to a birth cohort were followed at 3, 12, 24 and 48 months of age. Physical activity during pregnancy was assessed retrospectively at birth. Neurodevelopment was evaluated by Battelle's Development Inventory (12, 24 and 48 months) and IQ by the Weschler's Intelligence Scale (48 months). Neurodevelopment was based on Battelles' (90th percentile) and also analyzed as a continuous outcome. IQ was analyzed as a continuous outcome. Potential confounders were: family income, mother's age, schooling, skin color, number of previous births and smoking; and newborns': preterm birth, sex and low birth weight.
Results:
From birth to 48 months, sample size decreased from 4231 to 3792. Crude analysis showed that IQ at 48 months was slightly higher (5 points) among children from active women. The Battelle's score at 12 and 24 months was higher among offspring from active mothers. After controlling for confounders, physical activity during pregnancy was positively associated to the Battelle's Inventory at 12 months IQ, however, at 48 months no association was observed.
Conclusion:
Physical activity during pregnancy does not seem to impair children's neurodevelopment and children from active mothers presented better performance at 12 months.
Related Concept Videos
Environmental Influences on Intelligence
Biological Influences on Intelligence
Information Processing Approach
Socioemotional Development during Infancy
Primary Temperament Types
Teratogenicity
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...

