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Updated: Apr 21, 2026

Metabolic Glycoengineering of Sialic Acid Using N-acyl-modified Mannosamines
Published on: November 25, 2017
Functional importance of the sugar moiety of jasmonic acid glucoside for bioactivity and target affinity
Minoru Ueda1, Gangqiang Yang, Yuuki Nukadzuka
1Laboratory of Organic Chemistry, Department of Chemistry, Tohoku University, 6-3 Aramaki-Aza Aoba, Aoba-ku, Sendai 980-8578, Japan. ueda@m.tohoku.ac.jp.
Abstract:
12-O-β-D-Glucopyranosyljasmonic acid (JAG, 1) induces nyctinastic leaf-folding of Samanea saman. The SAR studies of 1 revealed the unique role of its glycone moiety. Biological activity and the target affinity of 1 were affected by the stereochemistry of the glycone moiety. JAG belongs to a unique class of ligands in which the structure of the glycone moiety is involved in the molecular recognition by the target protein.
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