Related Experiment Video
Updated: Apr 21, 2026
05:23
Murine Bioluminescent Hepatic Tumour Model
Published on: July 17, 2010
16.8K
Complete mitochondrial genome sequence and mutations of the liver cancer model inbred C57BL/6 mice strain
Sen Lu1, Yuan-Yuan Gao2, Wen-Yu Shao1
1a Department of Liver Surgery , The First Affiliated Hospital of Nanjing Medical University , Nanjing , Jiangsu Province , P.R. China .
Mitochondrial DNA. Part A, DNA Mapping, Sequencing, and Analysis
|October 29, 2014
Abstract:
In the present work, we undertook the complete mitochondrial genome sequencing of an important liver cancer model inbred rat strain for the first time. The total length of the mitogenome was 16,308 bp. It harbored 13 protein-coding genes, 2 ribosomal RNA genes, 22 transfer RNA genes and 1 non-coding control region (D-loop region). The mutation events were also reported.
Related Concept Videos
02:43Mouse Models of Cancer Study
4.7K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
4.7K
02:59Animal Mitochondrial Genetics
7.7K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
7.7K