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Updated: Apr 21, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
[Diagnosis and treatment of faciocervical lymphatic malformations in infant]
Jing Ma1, Zhiyong Mao1, Fan Lou1
1Department of Otorhinolaryngology, Kunming Children's Hospital (Children's Hospital Affiliated Kunming Medical University), Kunming 650228, China.
Insights
Surgical treatment effectively addresses infant head and neck lymphatic malformations (LMs). For large or microcystic LMs, pingyangmycin injection followed by secondary surgery can prevent complications.
Area of Science:
- Pediatric Surgery
- Vascular Anomalies
- Head and Neck Surgery
Background:
- Lymphatic malformations (LMs) are congenital vascular anomalies.
- Head and neck LMs present unique challenges in infant treatment.
- Effective management strategies are crucial to minimize morbidity.
Purpose of the Study:
- To evaluate the treatment outcomes of head and neck lymphatic malformations in infants.
- To compare the efficacy of different treatment modalities.
- To identify optimal management strategies for complex cases.
Main Methods:
- Retrospective analysis of 46 infant head and neck LMs (2009-2013).
- Patients aged 9 months to 4 years.
- Treatments included Phase I/II surgical resection and pingyangmycin injection.
Main Results:
- Surgical resection was performed in 28 cases.
- Pingyangmycin injection was used in 18 cases.
- Two complications occurred: facial nerve branch paralysis and accessory nerve injury, both improved with treatment.
Conclusions:
- Surgical intervention is an effective treatment for infant head and neck LMs.
- Pingyangmycin injection is a viable option for large or microcystic LMs.
- A staged approach, including secondary surgery, may be necessary for extensive LMs to avoid complications.
Objective:
To discuss the treatment effect of infant lymphatic malformations (LMs) located in the head and neck.
Methods:
Fourty-six LMs located in the head and neck between 2009 and 2013 were retrospectively analyzed. There were 26 males and 20 females, aged from 9 months to 4 years, with a median age of 1.8 years.
Results:
Phase Isurgical resection was performed in 28 cases. The low concentrations of pingyangmycin was injected in 18 cases, and Phase II surgical resection was performed in 6 cases after 6 months, because of the large tumors and a wide range of invasion. Two post-operative complications were found, one was minor paralyses of mandibular branch of facial nerve, manifestied as mouth askew. Another was injured accessory nerve, manifestied as right upper limb lifting weakness, which improved after rehabilitation treatment.
Conclusions:
Surgical treatment is effective to LMs. In order to avoid serious complications, the huge LMs and microcystic LMs may be given local injection of pingyangmycin after puncture fluid, and phase II surgical resection secondly if necessary.
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