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Related Concept Videos

Notch Signaling Pathway03:14

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Focus issue: Signaling in neuronal development, function, and disease.

Leslie K Ferrarelli1, Wei Wong2

  • 1Associate Editors of Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA. lferrare@aaas.org.

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Neurons coordinate communication for behavior and adaptation. Dysfunctional neuronal signaling underlies neurological disorders, impacting development and aging.

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Systems Biology

Background:

  • Neuronal communication is essential for behavior, learning, and environmental adaptation.
  • Proper function of neural circuits and their connections to peripheral tissues is critical for coordinated responses.
  • Disruptions in neuronal function are linked to developmental and age-related cognitive, motor, and behavioral disorders.

Discussion:

  • This content delves into the molecular mechanisms governing neuronal development and function.
  • It examines how these mechanisms are altered in conditions of neurological dysfunction.
  • Focus is placed on neurodegenerative diseases and their underlying molecular pathologies.

Key Insights:

  • Understanding molecular regulation of neuronal development is key to addressing neurological dysfunction.
  • Identifying altered signaling pathways in neurodegeneration offers therapeutic targets.
  • Coordination of neural circuits is fundamental to adaptive behavior.

Outlook:

  • Future research will continue to elucidate complex molecular pathways in neuronal health and disease.
  • Translational studies aim to link molecular insights to clinical interventions for neurological disorders.
  • Exploring the interplay between brain and peripheral tissues in neurological conditions is a growing area.