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Updated: Apr 21, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
Published on: June 28, 2021
[Fatal acute pancreatitis caused by severe hypertriglyceridaemia]
Osama Karim Abed1, Mats Lindberg, Shadi Andos
1Akutcentret, Sygehus Sønderjylland, Aabenraa, Kresten Philipsens Vej 15, 6200 Rødekro. osamakarim@hotmail.com.
A young man died from acute pancreatitis caused by extremely high triglycerides linked to quetiapine treatment. This case highlights the severe risks of hypertriglyceridemia and explores apheresis as a potential treatment.
Area of Science:
- Medicine
- Pharmacology
- Gastroenterology
Background:
- Antipsychotic medications like quetiapine can have various side effects.
- Hypertriglyceridemia, characterized by high triglyceride levels, is a known risk factor for pancreatitis.
- Acute pancreatitis is a sudden inflammation of the pancreas.
Observation:
- A 27-year-old male developed severe acute pancreatitis.
- The patient was undergoing treatment with quetiapine.
- Blood analysis revealed extremely high triglyceride levels (> 55 mmol/l), with a milk-like appearance.
- Computed tomography confirmed severe pancreatitis, ruling out gallstones or cholestasis.
Findings:
- The patient's condition rapidly deteriorated despite medical intervention.
- The case resulted in a fatal outcome 48 hours after admission.
- Severe hypertriglyceridemia was identified as the direct cause of the acute pancreatitis.
Implications:
- This case underscores the critical need to monitor triglyceride levels in patients treated with quetiapine.
- Early recognition and management of hypertriglyceridemia are crucial to prevent severe pancreatitis.
- Apheresis is presented as a potential therapeutic option for managing severe hypertriglyceridemia-induced pancreatitis.
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