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Related Experiment Video

Updated: Apr 21, 2026

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT

Published on: May 2, 2012

[Giant cell arteritis diagnosed by PET-CT scan].

Cæcilie Crawley Larsen¹, Søren Schifter, Steen Joop Bonnema

¹Endokrinologisk Afdeling, Odense Univer-sitetshospital, Sdr. Boulevard 29, 5000 Odense C. caecilielarsen@hotmail.com.

Ugeskrift for Laeger

|October 30, 2014

Summary

Giant cell arteritis (GCA) can present atypically. This case highlights how 18F-fluordeoxyglucose PET-CT imaging aided in diagnosing GCA in an elderly patient with pneumonia-like symptoms.

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Published on: February 8, 2019

Area of Science:

Vascular Medicine
Nuclear Imaging
Rheumatology

Background:

Giant cell arteritis (GCA) is a common vasculitis affecting large arteries, typically diagnosed via characteristic symptoms and temporal artery biopsy.
Atypical presentations of GCA can delay diagnosis and treatment, potentially leading to severe complications.

Observation:

An 82-year-old male presented with pneumonia-like symptoms including weight loss and fever, unresponsive to antibiotics.
18F-fluordeoxyglucose PET-CT imaging revealed increased uptake in the thoracic aorta, suggesting an inflammatory process.

Findings:

The PET-CT findings raised suspicion for GCA, prompting further investigation.
A temporal artery biopsy confirmed the diagnosis of Giant Cell Arteritis.
The patient showed significant improvement after initiating high-dose prednisolone treatment.

Implications:

This case underscores the utility of 18F-fluordeoxyglucose PET-CT in diagnosing GCA, especially in patients with non-specific or atypical symptoms.
Early and accurate diagnosis of GCA is crucial to prevent irreversible complications such as vision loss or stroke.
Integrating advanced imaging techniques like PET-CT can enhance diagnostic accuracy for challenging GCA cases.