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Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
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[Growth hormone deficiency in children]

Jon Nielsen, Rikke Beck Jensen, Anders Juul1

  • 1Afdeling for Vækst og Reproduktion, Rigshospi-talet, Blegdamsvej 9, 2100 København Ø. anders.juul@ regionh.dk.

Ugeskrift for Laeger
|October 30, 2014
PubMed

Insights

Growth hormone (GH) deficiency can cause early or later childhood growth deceleration. Diagnosis involves auxological measurements, bone age, and biochemical tests, with treatment adjusted based on growth and IGF-I levels.

Area of Science:

  • Pediatric Endocrinology
  • Growth Hormone Therapy
  • Child Development

Background:

  • Growth hormone (GH) deficiency can manifest congenitally or in childhood, leading to growth deceleration.
  • Early identification and intervention are crucial for optimal outcomes in affected children.

Purpose of the Study:

  • To outline the diagnostic procedures for suspected GH deficiency in short-statured children.
  • To describe the management and monitoring of GH therapy.
  • To emphasize the importance of re-evaluating GH secretion during transitional care.

Main Methods:

  • Utilizing updated national growth references for auxological measurements.
  • Determining bone age through skeletal imaging.
  • Conducting biochemical evaluations to assess GH status.
  • Monitoring serum insulin-like growth factor-I (IGF-I) concentrations.

Main Results:

  • GH deficiency diagnosis relies on a combination of auxological, skeletal, and biochemical assessments.
  • GH dosage adjustments are guided by height changes and IGF-I levels every three months.
  • Re-evaluation of GH secretion is necessary post-linear growth cessation.

Conclusions:

  • Comprehensive diagnostic evaluation is essential for identifying GH deficiency in pediatric patients.
  • Personalized GH dosing and regular monitoring ensure effective treatment.
  • Transitioning care requires reassessment of GH status for long-term management.

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