[Growth hormone deficiency in children]

Area of Science:

• Pediatric Endocrinology
• Growth Hormone Therapy
• Child Development

Background:

• Growth hormone (GH) deficiency can manifest congenitally or in childhood, leading to growth deceleration.
• Early identification and intervention are crucial for optimal outcomes in affected children.

Purpose of the Study:

• To outline the diagnostic procedures for suspected GH deficiency in short-statured children.
• To describe the management and monitoring of GH therapy.
• To emphasize the importance of re-evaluating GH secretion during transitional care.

Main Methods:

• Utilizing updated national growth references for auxological measurements.
• Determining bone age through skeletal imaging.
• Conducting biochemical evaluations to assess GH status.
• Monitoring serum insulin-like growth factor-I (IGF-I) concentrations.

Main Results:

• GH deficiency diagnosis relies on a combination of auxological, skeletal, and biochemical assessments.
• GH dosage adjustments are guided by height changes and IGF-I levels every three months.
• Re-evaluation of GH secretion is necessary post-linear growth cessation.

Conclusions:

• Comprehensive diagnostic evaluation is essential for identifying GH deficiency in pediatric patients.
• Personalized GH dosing and regular monitoring ensure effective treatment.
• Transitioning care requires reassessment of GH status for long-term management.