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Updated: Apr 21, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

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Normal Myocardial Perfusion Gated SPECT and Positive Stress Test: Different Prognoses in Women and Men

Guillermo Romero-Farina1, Jaume Candell-Riera, Ignacio Ferreira-González

  • 1Cardiology Department, Hospital Universitari Vall d'Hebron, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Paseo Vall d'Hebron 119-129, Barcelona, 08035, Spain, guirom@adinet.com.uy.

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
|October 30, 2014
PubMed

Insights

Men with abnormal stress tests and normal myocardial perfusion gated SPECT have a worse prognosis than women. This study highlights sex-based differences in cardiac event risk despite normal imaging.

Area of Science:

  • Cardiology
  • Nuclear Cardiology
  • Cardiovascular Imaging

Background:

  • Myocardial perfusion gated SPECT assesses heart function.
  • Stress test results can indicate underlying coronary artery disease.
  • Prognostic differences between sexes in cardiac conditions warrant investigation.

Purpose of the Study:

  • To compare prognoses in women and men with normal myocardial perfusion gated SPECT.
  • To analyze the impact of stress test results on cardiac event rates in both sexes.

Main Methods:

  • Analysis of 2,414 patients with normal stress-rest gated SPECT.
  • Evaluation of hard events (HE) and HE plus coronary revascularization (HE + CR).
  • Stratification based on sex and positive or negative stress test results.

Main Results:

  • Men with positive stress tests had significantly higher rates of HE and HE + CR compared to men with negative stress tests.
  • No significant differences in HE or HE + CR were observed between women with positive and negative stress tests.
  • Multivariate analysis confirmed a higher risk of HE and HE + CR in men with positive stress tests versus women with positive stress tests.

Conclusions:

  • Normal gated SPECT indicates a generally favorable prognosis.
  • Men with abnormal stress tests exhibit a more adverse prognosis compared to women, irrespective of normal SPECT findings.
  • Sex-specific risk stratification may be beneficial in patients with normal myocardial perfusion imaging.
Abstract

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