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Antibiotic-resistant gram-negative bacterial infections in patients with cancer
Federico Perez1, Javier Adachi2, Robert A Bonomo1
1Medical and Research Services, Louis Stokes Cleveland Veterans Affairs Medical Center Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio;
Abstract:
Patients with cancer are at high risk for infections caused by antibiotic resistant gram-negative bacteria. In this review, we summarize trends among the major pathogens and clinical syndromes associated with antibiotic resistant gram-negative bacterial infection in patients with malignancy, with special attention to carbapenem and expanded-spectrum β-lactam resistance in Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia--all major threats to our cancer patients. Optimal therapy for these antibiotic-resistant pathogens still remains to be determined.
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