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Beta-endorphin levels in the human menstrual cycle.
C J Chuong1, E R Smith, Y Tsong
1Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston.
Acta Obstetricia Et Gynecologica Scandinavica
|January 1, 1989
Summary
Plasma beta-Endorphin (beta-EP) levels fluctuate during the menstrual cycle, with significant rises observed during the follicular, periovulatory, and luteal phases. These findings suggest beta-EP may play a role in regulating ovulation.
Area of Science:
- Endocrinology
- Reproductive Biology
- Neuroendocrinology
Background:
- The menstrual cycle involves complex hormonal fluctuations impacting various physiological processes.
- Beta-Endorphin (beta-EP), an endogenous opioid peptide, is known to interact with the hypothalamic-pituitary-gonadal axis.
Purpose of the Study:
- To investigate the dynamic changes in plasma beta-Endorphin (beta-EP) concentrations throughout the normal menstrual cycle.
- To explore the potential relationship between beta-EP secretion patterns and the hormonal events of the menstrual cycle, including LH and FSH.
Main Methods:
- Studied 8 healthy females with regular menstrual cycles.
- Collected blood samples every 2-4 days over three menstrual cycles, timed relative to the LH surge (Day 0).
- Measured plasma beta-EP concentrations using established assays.
Main Results:
- Plasma beta-EP concentrations exhibited distinct fluctuations across the menstrual cycle.
- Elevated beta-EP levels were observed during the late follicular phase (Days -10 to -8), periovulatory phase (Days -1 to +1), and mid-luteal phase (Days +9 and +12).
- Beta-EP levels were generally lowest during the menstrual phase.
Conclusions:
- Three distinct rises in beta-EP concentration occur during the menstrual cycle.
- Beta-Endorphin may be implicated in the regulation of ovulation and reproductive processes.