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Post-prandial and daily changes in plasma zinc
K M Hambidge1, M J Goodall, C Stall
1University of Colorado Health Sciences Center, Department of Pediatrics, Denver 80262.
Journal of Trace Elements and Electrolytes in Health and Disease
|March 1, 1989
Summary
Meals significantly impact plasma zinc levels throughout the day. This study shows daily zinc fluctuations are primarily driven by meal timing and consumption in healthy women.
Area of Science:
- Nutritional Science
- Human Physiology
- Biochemistry
Background:
- Plasma zinc concentrations exhibit diurnal variations.
- Understanding these fluctuations is crucial for nutritional assessment and health monitoring.
Purpose of the Study:
- To investigate the 24-hour changes in plasma zinc concentrations.
- To determine the relationship between meal intake and plasma zinc levels.
Main Methods:
- Hourly plasma zinc levels were measured in 12 healthy adult women over 24 hours.
- Standard meals were administered at 0700, 1200, and 1700 hours.
Main Results:
- Plasma zinc declined 1.5 to 2.5 hours after each meal, reaching lowest levels 3-4 hours post-meal.
- Overnight, plasma zinc increased progressively, averaging 1.54 µg/dL/h for 11 hours.
- The lowest daily plasma zinc value (at 2100 hours) was 22% lower than the highest (at 0730 hours).
Conclusions:
- Meal consumption is the primary determinant of daily plasma zinc variations.
- Dietary intake is likely the sole factor influencing diurnal plasma zinc fluctuations.