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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
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Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

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Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
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Reticular Dermis01:15

Reticular Dermis

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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
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Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

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A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
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Granulocyte-dependent Autoantibody-induced Skin Blistering
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Interface dermatitis along Blaschko's lines.

Mariah Johnson1, Daniel Walker, William Galloway

  • 1Department of Dermatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Journal of Cutaneous Pathology
|October 30, 2014
PubMed
Summary
This summary is machine-generated.

Adult blaschkitis, a rare inflammatory skin condition, can present with varied histopathology, sometimes mimicking erythema multiforme. Understanding its clinicopathologic spectrum with lichen striatus is key for accurate diagnosis.

Keywords:
blaschkitisinterfacelichen striatuslinearspongiotic

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Area of Science:

  • Dermatology
  • Pathology
  • Genetics

Background:

  • Linear dermatoses may indicate embryologically derived cutaneous mosaicism.
  • Adult blaschkitis is a rare, relapsing inflammatory dermatitis typically presenting in middle age.
  • Lichen striatus in adults can share clinical and histopathologic features with adult blaschkitis.

Observation:

  • A case of suspected adult blaschkitis presented with non-characteristic biopsy findings resembling erythema multiforme.
  • This histopathologic finding is rarely reported in the literature for adult blaschkitis.

Findings:

  • The study expands the known histopathologic findings for adult blaschkitis.
  • It highlights the clinical and histopathologic overlap between adult blaschkitis and lichen striatus.
  • These conditions may represent a clinicopathologic spectrum.

Implications:

  • Accurate diagnosis of linear eruptions requires thorough clinicopathologic correlation.
  • Recognizing a broader range of histopathologic presentations aids in diagnosing adult blaschkitis.
  • Understanding the spectrum may refine diagnostic criteria and treatment approaches for these linear dermatoses.