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Updated: Apr 21, 2026

Sample Preparation in Quartz Crystal Microbalance Measurements of Protein Adsorption and Polymer Mechanics
Published on: January 22, 2020
Effect of interfacial viscoelasticity on the bulk linear viscoelastic moduli of globular protein solutions
Zhenhuan Zhang1, Sourav Barman1, Gordon F Christopher1
1Department of Mechanical Engineering, Texas Tech University, Lubbock, Texas 79409, USA.
Abstract:
The role of interfacial rheology on the bulk linear viscoelastic moduli of low concentration bovine albumin solutions is probed. Previously reported soft gel properties of these systems were attributed to either protein aggregation or organization within the bulk. Instead, these behaviors are shown to be attributable to the measurement error caused by interfacial rheology due to adsorption of bovine serum albumin to the air and water interface. Even at low bulk concentrations, fast interfacial adsorption results in erroneous measurements. When these effects are removed, the solutions are viscous dominated with a dynamic viscosity slightly larger than water.
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