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Three-dimensional imaging techniques are essential in cell biology, allowing researchers to visualize intricate cellular structures with high resolution. Two prominent methods, Differential Interference Contrast Microscopy (DIC) and Confocal Scanning Laser Microscopy (CSLM), provide distinct advantages for imaging live and thick specimens, respectively.Differential Interference Contrast MicroscopyDIC microscopy enhances contrast in transparent, unstained samples by converting phase...
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Three dimensional (3D) histology in daily routine: practical implementation and its evaluation.

Franziska Carola Eberle1, Mukaddes Kanyildiz, Saskia Maria Schnabl

  • 1Department of Dermatology, Eberhard Karls Universität Tübingen, Germany.

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
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Standardized three-dimensional (3D) histology rules improve communication and reduce basal cell carcinoma recurrence rates. This method effectively identifies high-risk tumors, such as sclerodermiform types, for better patient outcomes.

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Area of Science:

  • Dermatopathology
  • Surgical Oncology
  • 3D Histology

Background:

  • Evaluating tumor margins with 3D histology is complex, necessitating close surgeon-dermatopathologist collaboration.
  • Clear communication protocols are essential for effective tumor edge assessment.

Purpose of the Study:

  • To present and validate standardized rules for 3D histology communication.
  • To assess the impact of these rules on basal cell carcinoma recurrence rates in clinical practice.

Main Methods:

  • An algorithm-based approach for tissue processing, result interpretation, and interdisciplinary communication was implemented.
  • Precise topographic orientation was achieved using specific timings and embedding cassettes.
  • The method's efficacy was evaluated on 947 operated basal cell carcinomas, monitoring for tumor recurrence.

Main Results:

  • A low recurrence rate of 1.1% (10 out of 947) was observed at a median follow-up of 47 months.
  • Sclerodermiform basal cell carcinomas exhibited a significantly higher recurrence rate (p < 0.05).
  • Basal cell carcinomas with incomplete initial resection (non-R0) showed a significantly higher recurrence rate (p < 0.001).

Conclusions:

  • Standardized protocols for excised tissue handling facilitate the effective use of 3D histology in clinical settings.
  • The application of 3D histology is associated with reduced basal cell carcinoma recurrence.
  • Sclerodermiform basal cell carcinomas with non-R0 resection represent a high-risk group for recurrence.