Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

7.8K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
7.8K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

5.0K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.0K
Connective Tissue Cell Types01:22

Connective Tissue Cell Types

3.3K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
3.3K
Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

50
Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
50
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

14.1K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
14.1K
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

3.3K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Effect of Iodinated Contrast Media on Thyroid (Dys)function in Children.

European thyroid journal·2026
Same author

Case-Control and Longitudinal Study of Sex Steroids in Male Patients with CKD Before and After Kidney Transplantation.

Kidney international reports·2026
Same author

Adsorption represents a critical challenge in the quantification of free 25-hydroxyvitamin D3.

Journal of molecular endocrinology·2026
Same author

Inducible kidney-selective knockdown of Cyp27b1 does not compromise calcium and bone homeostasis.

Journal of endocrinological investigation·2026
Same author

The role of 4DCT in the localization of parathyroid adenomas in primary hyperparathyroidism: a retrospective cohort study.

Insights into imaging·2025
Same author

rhPTH(1-84) for hypoparathyroidism: a randomized study of patient-reported outcomes.

European journal of endocrinology·2025

Related Experiment Video

Updated: Apr 21, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

10.3K

Vitamin D for infections.

Hannelie Korf1, Brigitte Decallonne, Chantal Mathieu

  • 1Clinical and Experimental Endocrinology, Department of Experimental and Clinical Medicine, KU Leuven, Leuven, Belgium.

Current Opinion in Endocrinology, Diabetes, and Obesity
|October 30, 2014
PubMed
Summary
This summary is machine-generated.

Vitamin D plays a crucial role in the immune system by activating antimicrobial peptides to fight infections. This review explores vitamin D

More Related Videos

Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses
10:10

Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses

Published on: November 16, 2016

12.5K
In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
08:02

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction

Published on: January 22, 2020

4.9K

Related Experiment Videos

Last Updated: Apr 21, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

10.3K
Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses
10:10

Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses

Published on: November 16, 2016

12.5K
In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
08:02

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction

Published on: January 22, 2020

4.9K

Area of Science:

  • Immunology
  • Endocrinology
  • Infectious Diseases

Background:

  • Immune cells express the vitamin D receptor (VDR).
  • Immune cells can metabolize 25-hydroxyvitamin D to its active form, 1,25-dihydroxyvitamin D.
  • Vitamin D regulates both innate and adaptive immune systems.

Purpose of the Study:

  • To review the mechanisms of vitamin D in innate immunity against infectious agents.
  • To discuss the implications of vitamin D for preventing and treating infectious diseases.

Main Methods:

  • Literature review of current data on vitamin D and immune interactions.
  • Analysis of studies investigating vitamin D's role in antimicrobial peptide production.
  • Examination of pathogen-induced modulation of vitamin D metabolism.

Main Results:

  • 1,25-dihydroxyvitamin D triggers antimicrobial peptide production, aiding pathogen clearance.
  • Pathogen-derived components can influence vitamin D metabolism pathways.
  • Vitamin D interaction with immune cells is independent of calcium homeostasis.

Conclusions:

  • Vitamin D enhances innate immune responses against pathogens.
  • Vitamin D holds potential for preventing and intervening in infectious diseases.
  • Further research is warranted to elucidate vitamin D's therapeutic applications in infectious diseases.