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An evolutionary model encompassing substrate specificity and reactivity of type I polyketide synthase thioesterases

Taylor P A Hari1, Puneet Labana, Meaghan Boileau

  • 1Departments of Chemistry and Biology, Centre for Catalysis Research and Innovation, University of Ottawa, Ottawa, ON K1N 6N5 (Canada).

Chembiochem : a European Journal of Chemical Biology
|October 30, 2014
PubMed
Summary

Bacterial thioesterases (TEs) can produce diverse polyketides, including macrodiolides. Evolution favors TEs that enhance beneficial metabolites, driving diversity in drug discovery.

Keywords:
macrodiolidemacrolactonescreening hypothesissubstrate selectivitythioesterase

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