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Protein-protein Interfaces

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...

Protein-Protein Interfaces

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Updated: Apr 21, 2026

Bridging the Bio-Electronic Interface with Biofabrication

Bridging the Bio-Electronic Interface with Biofabrication

Published on: June 6, 2012

Dynamic biointerfaces: from recognition to function.

Baisong Chang¹, Mingxi Zhang, Guangyan Qing

¹State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, 430070, PR China.

Small (Weinheim an Der Bergstrasse, Germany)

|October 31, 2014

Summary

This summary is machine-generated.

Engineered dynamic biointerfaces mimic nature's weak interactions and chirality. These biomimetic materials translate molecular recognition into macroscopic biological functions, advancing life science applications.

Keywords:

H-bonding interactions biointerfaces biological functions chirality dynamic biointerfaces molecular recognition

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Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

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Published on: March 9, 2017

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Last Updated: Apr 21, 2026

Bridging the Bio-Electronic Interface with Biofabrication

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Published on: June 6, 2012

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

Published on: March 9, 2017

Area of Science:

Materials Science
Biomimetics
Surface Chemistry

Background:

Engineering artificial materials to regulate biological entities is challenging.
Nature utilizes weak interactions and chirality for complex biological functions.
Dynamic biointerfaces offer a biomimetic approach to bridge molecular recognition and macroscopic behavior.

Purpose of the Study:

To review emerging progresses in dynamic biointerfaces.
To highlight the role of dynamic biointerfaces in molecular recognition and biological functions.
To discuss the integration of dynamic biointerfaces with biochemical processes for life science challenges.

Main Methods:

Leveraging nature's principles of weak interactions and chirality.
Designing dynamic biointerfaces with tailored molecular assemblies responsive to stimuli.
Utilizing biomolecules to induce conformational transitions and switch surface characteristics.

Main Results:

Dynamic biointerfaces can translate molecular recognition signals into macroscopic behaviors.
Surface characteristics like topography and wettability can be switched via conformational transitions.
Synergetic chiral H-bonding interactions are key for selective molecular assembly.

Conclusions:

Dynamic biointerfaces represent a significant advancement in biomimetic engineering.
These interfaces show potential for solving major challenges in life science.
Further integration with biochemical processes is crucial for future applications.