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Getting the better of ER stress

Bertrand Mollereau1, Serge Manié, Francesco Napoletano

  • 1Laboratory of Molecular Biology of the Cell, UMR5239 CNRS/Ecole Normale Supérieure de Lyon, UMS 3444 Biosciences Lyon Gerland, University of Lyon, Lyon, France, bertrand.mollereau@ens-lyon.fr.

Journal of Cell Communication and Signaling
|October 31, 2014
PubMed
Summary

Low levels of endoplasmic reticulum (ER) stress trigger an adaptive unfolded protein response (UPR), known as ER hormesis. This protective mechanism preconditions cells against subsequent lethal insults, offering therapeutic potential for diseases linked to protein misfolding.

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