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Association between Helicobacter pylori infection and migraine: a meta-analysis

Jing Su1, Xiao-Ying Zhou1, Guo-Xin Zhang1

  • 1Jing Su, Xiao-Ying Zhou, Guo-Xin Zhang, Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.

World Journal of Gastroenterology
|October 31, 2014
PubMed
Abstract

Insights

Helicobacter pylori (H. pylori) infection is more common in migraine patients. This meta-analysis found a higher prevalence of H. pylori in individuals suffering from migraines compared to healthy controls.

Area of Science:

  • Gastroenterology
  • Neurology
  • Epidemiology

Background:

  • Migraine is a common neurological disorder.
  • Helicobacter pylori (H. pylori) is a bacterium linked to various gastrointestinal issues.
  • The potential association between H. pylori infection and migraine requires further investigation.

Purpose of the Study:

  • To systematically review and quantify the association between H. pylori infection and migraine.
  • To determine if H. pylori infection prevalence differs significantly between migraineurs and healthy individuals.

Main Methods:

  • A systematic literature search was performed on PubMed and EMBASE up to December 2013.
  • Meta-analysis of five case-control studies involving 903 participants was conducted.
  • Odds ratios (OR) and 95% confidence intervals (CI) were calculated to assess the association.

Main Results:

  • The overall prevalence of H. pylori infection was 39.31%.
  • Migraineurs exhibited a significantly higher prevalence of H. pylori infection (44.97%) compared to controls (33.26%), with an OR of 1.92 (95%CI: 1.05-3.51, P = 0.001).
  • Subgroup analysis revealed a significantly higher H. pylori infection rate in Asian migraine patients (OR = 3.48) but not in European patients (OR = 1.19).

Conclusions:

  • Pooled data suggest a trend indicating more frequent H. pylori infections in patients experiencing migraines.
  • The findings highlight a potential link between H. pylori and migraine, particularly in Asian populations.
Keywords:
Helicobacter pyloriMeta-analysisMigraineOdds ratioSubgroup analysis

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