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Related Concept Videos

Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

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Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
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The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

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Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Intestinal Obstruction II: Pathophysiology01:07

Intestinal Obstruction II: Pathophysiology

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Intestinal obstruction triggers a series of physiological responses, starting with gas and fluid accumulation in the bowel segment proximal to the obstruction, leading to distension. This distended intestine compresses the diaphragm, hindering lung expansion and potentially leading to reduced respiratory effort, atelectasis, and pneumonia.To overcome the blockage, the gut intensifies contractions, causing colicky abdominal pain, nausea, and vomiting, which reduces fluid and food intake and...
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Ileectomy-induced Bile Overaccumulation in Mouse Intestine
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Sickle cell diseases and ileus.

Mehmet Rami Helvaci1, Akin Aydogan1, Seckin Akkucuk1

  • 1Medical Faculty of The Mustafa Kemal University Turkey.

International Journal of Clinical and Experimental Medicine
|October 31, 2014
PubMed
Summary

Ileus incidence is significantly higher in males with sickle cell disease (SCD). Treatment with red blood cell transfusions is effective for SCD-related ileus, avoiding surgery.

Keywords:
Sickle cell diseasesatherosclerosischronic endothelial damageileus

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Area of Science:

  • Hematology
  • Gastroenterology
  • Vascular Medicine

Background:

  • Sickle cell disease (SCD) is a complex condition with various complications.
  • The incidence of ileus in SCD patients requires further investigation.

Purpose of the Study:

  • To determine the incidence of ileus in patients with sickle cell diseases.
  • To explore potential risk factors and treatment outcomes for ileus in SCD.

Main Methods:

  • A retrospective study including all patients diagnosed with SCD.
  • Analysis of patient demographics, clinical data, and ileus incidence.

Main Results:

  • Ileus occurred in 3.6% of males versus 1.2% of females with SCD (p < 0.01).
  • Males exhibited higher rates of smoking, elevated hematocrit, and more comorbidities.
  • All ileus cases were successfully treated with red blood cell transfusions, without surgical intervention.

Conclusions:

  • The high incidence of ileus in SCD patients may be linked to the disease's atherosclerotic and obstructive characteristics.
  • Red blood cell transfusions are a viable and effective treatment for restoring bowel perfusion in SCD-related ileus.