Related Experiment Video
Updated: Apr 21, 2026
09:57
A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
8.3K
A case of extravascular hemolysis with Tk-activation
Chisa Yamada1, Robertson D Davenport1
1Transfusion Medicine Division, Department of Pathology, University of Michigan Ann Arbor, Michigan.
Clinical Case Reports
|October 31, 2014
Summary
A patient with ovarian cancer developed unexplained extravascular hemolysis after antibiotic treatment. Further blood bank investigations are crucial to identify this rare cause of red blood cell destruction.
Area of Science:
- Hematology
- Oncology
- Clinical Chemistry
Background:
- A 50-year-old female with a 4-year history of ovarian cancer presented with abdominal pain.
- The patient developed extravascular hemolysis following the initiation of antibiotic therapy for a suspected infection.
Purpose of the Study:
- To investigate the cause of unexplained extravascular hemolysis in a patient with ovarian cancer.
- To explore potential rare immunological mechanisms contributing to hemolysis.
Main Methods:
- Standard antigen detection tests were performed.
- A lectin panel was utilized to investigate red blood cell surface interactions.
- Collaboration with the blood bank was initiated for further specialized testing.
Main Results:
- All routine red blood cell antigen detection tests yielded negative results.
- Lectin panel testing indicated possible Tk-antigen activation, suggesting an atypical immune mechanism.
- The specific cause of hemolysis remained undetermined pending further investigation.
Conclusions:
- The patient's hemolysis was not explained by common alloimmune or autoimmune mechanisms.
- Tk-activation is a potential, albeit rare, cause of hemolysis that warrants further investigation.
- Comprehensive laboratory and blood bank testing is essential for diagnosing rare hemolytic conditions.
Related Concept Videos
01:01Hypersensitivity Reactions: Cytolytic Reactions
196
Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
196
01:20Extrinsic and Intrinsic Pathways of Hemostasis
10.6K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
10.6K
01:25Bioactivation and Tissue Toxicity
145
Bioactivation is a metabolic process that transforms less reactive substances into highly reactive metabolites, initiating tissue toxicity. This transformation can lead to various toxic effects, including carcinogenesis and teratogenesis. Reactive metabolites are classified into two main types: electrophiles and free radicals.Electrophiles are electron-deficient species and are produced primarily by the enzyme cytochrome P-450 during the metabolism of compounds containing carbon, nitrogen, or...
145
01:25Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration
371
Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
371
01:24Disorders of Hemostasis
2.6K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
2.6K
01:29Hypersensitivity Reactions: Delayed Hypersensitivity Reactions
333
Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
333