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Pandoraea pulmonicola chronic colonization in a cystic fibrosis patient, France

S Kokcha1, F Bittar1, M Reynaud-Gaubert2

  • 1Pôle des Maladies Infectieuses, Assistance Publique-Hôpitaux de Marseille et URMITE UMR CNRS-IRD 6236, IFR48, Faculté de Médecine et de Pharmacie, Université de la Méditerranée Marseille, France.

New Microbes and New Infections
|October 31, 2014
PubMed

Insights

Pandoraea pulmonicola is an emerging multidrug-resistant pathogen in cystic fibrosis patients. This case highlights a fatal Pseudomonas aeruginosa sepsis following lung transplantation in a chronically infected patient.

Area of Science:

  • Medical microbiology
  • Infectious diseases
  • Pulmonology

Background:

  • Pandoraea species are increasingly recognized as multidrug-resistant pathogens.
  • Cystic fibrosis (CF) patients are susceptible to chronic respiratory infections.

Purpose of the Study:

  • To report the first case of chronic Pandoraea pulmonicola infection in a cystic fibrosis patient.
  • To describe the clinical course and outcome in a lung transplant recipient.

Main Methods:

  • Case report of a 30-year-old female cystic fibrosis patient.
  • Documentation of chronic Pandoraea pulmonicola infection.
  • Monitoring of post-lung transplantation course and complications.

Main Results:

  • The patient experienced chronic infection with Pandoraea pulmonicola.
  • She developed Pseudomonas aeruginosa sepsis three weeks after bilateral lung transplantation.
  • The patient ultimately died due to sepsis.

Conclusions:

  • Pandoraea pulmonicola represents a significant emerging threat in cystic fibrosis.
  • Chronic Pandoraea infection may complicate lung transplantation outcomes.
  • Multidrug resistance in Pandoraea necessitates careful management strategies.
Keywords:
Antibiotic resistancePandoraealung transplantationmulti-drug resistant bacteriapulmonary infection

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