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Association between retinol binding protein 4 with atherosclerotic markers in obese children

Nalini Santanam1, Yoram Elitsur, Ronald Stanek

  • 1Department of Pharmacology, Physiology and Toxicology, Joan C Edwards School of Medicine, Marshall University, Huntington, WV, USA - santanam@marshall.edu.

Minerva Endocrinologica
|October 31, 2014
PubMed

Insights

Obese children show higher levels of Retinol-binding protein-4 (RBP4) and oxidized-low-density lipoprotein (Ox-LDL), which are linked to increased cardiovascular risk. These markers correlate with higher BMI and waist circumference in pediatric obesity.

Area of Science:

  • Pediatric Endocrinology
  • Cardiovascular Risk Factors
  • Adipokine Research

Background:

  • Childhood obesity is a growing concern, significantly increasing adult cardiovascular disease risk.
  • Retinol-binding protein-4 (RBP4), a pro-inflammatory adipokine, is implicated in obesity, insulin resistance, and adult atherogenesis.
  • Understanding RBP4's role in pediatric obesity is crucial for early cardiovascular risk assessment.

Purpose of the Study:

  • To investigate the relationship between RBP4 and key atherogenic markers in obese children.
  • To explore correlations between RBP4, oxidized-low-density lipoprotein (Ox-LDL), and anthropometric measures in pediatric obesity.

Main Methods:

  • A cross-sectional study involving obese and non-obese children aged 8-18 years.
  • Measurement of clinical markers including lipid profile, HbA1c, insulin resistance markers, plasma RBP4, sVCAM-1, and Ox-LDL.
  • Analysis of correlations between RBP4, Ox-LDL, and anthropometric indices like Body Mass Index (BMI) and waist circumference.

Main Results:

  • Obese children exhibited significantly higher plasma levels of RBP4 (P=0.016) and Ox-LDL (P<0.001) compared to non-obese peers.
  • Both RBP4 and Ox-LDL showed positive correlations with Body Mass Index (BMI) (P<0.001), BMI-SDS (P<0.001), and waist circumference (P=0.03).

Conclusions:

  • Elevated RBP4 and Ox-LDL are associated with obesity in children.
  • These findings suggest RBP4 and Ox-LDL may serve as early indicators of cardiovascular risk in pediatric obesity.
  • No significant correlations were observed between inflammatory markers and Homeostatic Model Assessment-2, HDL, triglycerides, or HbA1c in the studied obese children.
Abstract

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