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Caspase-9 mediates Puma activation in UCN-01-induced apoptosis

C Nie1, Y Luo1, X Zhao1

  • 1The State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center of Biotherapy, West China Hospital and College of Life Science, Sichuan University, No. 17 People's South Road, Chengdu 610041, People's Republic of China.

Cell Death & Disease
|October 31, 2014
PubMed
Summary

The protein kinase inhibitor UCN-01 triggers Puma-induced apoptosis via the Akt-FoxO3a pathway. Caspase-9 plays a key role in this process, mediating feedback loops that enhance Puma activation and sensitize cancer cells to UCN-01.

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