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Acetal-linked branched poly(dimethyl-aminoethyl methacrylate) as an acid cleavable gene vector with reduced
1Key Laboratory for Ultrafine Materials of Ministry of Education, and Shanghai Key Laboratory of Advanced Polymeric Materials, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China. caohl@ecust.edu.cn.
Chemical Communications (Cambridge, England)
|October 31, 2014
Abstract:
An acid labile branched PDMAEMA/acetal copolymer with amino group was synthesized by the DE-ATRP and followed by Michael addition. The degradation of the polymer was strongly pH-dependent. High nucleic acid transfection efficiency with low cytotoxicity was observed compared to its non-degradable copolymer counterpart.
