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Coronary collateral circulation in patients with chronic coronary total occlusion; its relationship with cardiac risk

A Börekçi1, M Gür2, T Şeker3

  • 1Department of Cardiology, Kafkas University School of Medicine, Kars, Turkey.

Perfusion
|November 1, 2014
PubMed

Insights

Well-developed coronary collateral circulation (CCC) is linked to lower cardiac mortality. Key cardiac risk markers, including N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitive cardiac troponin T (hs-cTnT), are independently associated with CCC.

Area of Science:

  • Cardiology
  • Cardiovascular Research

Background:

  • Well-developed coronary collateral circulation (CCC) is associated with reduced long-term cardiac mortality in patients with coronary artery disease.
  • Cardiovascular risk markers like NT-proBNP, hs-CRP, and hs-cTnT are established predictors of cardiovascular mortality.

Purpose of the Study:

  • To investigate the relationship between the development of coronary collateral circulation (CCC) and key cardiovascular risk markers.
  • To assess the association between CCC and biochemical markers in patients with stable coronary artery disease and chronic total occlusion.

Main Methods:

  • Prospective enrollment of 427 stable coronary artery disease patients with chronic total occlusion.
  • Patients were stratified into poorly developed (Rentrop 0-1) and well-developed (Rentrop 2-3) CCC groups.
  • Measurement of NT-proBNP, hs-CRP, hs-cTnT, uric acid, and calculation of SYNTAX score.

Main Results:

  • Patients with poorly developed CCC exhibited higher frequencies of diabetes and hypertension.
  • Elevated levels of hs-cTnT, hs-CRP, NT-proBNP, uric acid, neutrophil count, and mean platelet volume (MPV) were observed in the poorly developed CCC group.
  • Multivariate analysis identified hs-cTnT, NT-proBNP, hs-CRP, and diabetes as independent predictors of CCC.

Conclusions:

  • Cardiac risk markers, specifically NT-proBNP, hs-cTnT, and hs-CRP, demonstrate an independent association with CCC.
  • These findings highlight the clinical relevance of assessing cardiovascular risk markers in patients with coronary artery disease and chronic total occlusion.
Abstract

Keywords:
C-reactive proteinRentropSYNTAXbrain natriuretic peptidecollateral circulationhigh-sensitive troponin-T

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