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Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
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In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.
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Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
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Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
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Authors' reply

Andrea Smargiassi1, Riccardo Inchingolo, Francesco Faita

  • 1Pulmonary Medicine Department, Università Cattolica del Sacro Cuore, Rome, Italy.

Respiration; International Review of Thoracic Diseases
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No abstract available in PubMed .

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