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Updated: Apr 21, 2026

Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis
Published on: January 9, 2026
Fibrinogen and von Willebrand factor and susceptibility vessel sign on T2*-weighted gradient echo imaging
Ahmed Farghali1, Michel Hanss, Julien Berthiller
1Centre d'Urgences Cerebrovasculaires, Hôpital Pierre Wertheimer, Hospices Civils de Lyon CREATIS, Lyon, France.
Background:
We investigated the relationship between von Willebrand factor (vWF), fibrin monomers (FM), fibrinogen baseline levels and the presence of susceptibility vessel sign (SVS) on T2*-weighted gradient echo imaging in acute ischemic stroke.
Methods:
SVS was assessed at admission using T2*-weighted GRE. Plasmatic levels of vWF, FM and fibrinogen were evaluated before the initiation of intravenous thrombolysis.
Results:
Forty-four patients were enrolled in this study. SVS was noted in 26 patients. Univariate analysis revealed that vWF >160% (p = 0.02) and fibrinogen >4 g/l (p = 0.03) were associated with a significant decrease in the likelihood of SVS. Multivariate analysis confirmed that higher levels of vWF or fibrinogen predicted the absence of SVS.
Conclusions:
The increased activity of vWF may promote a fibrin-platelet recruitment mainly contributing to the absence of (SVS).
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