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Diagnostic performance of computed tomography for detection of concomitant coronary disease in hypertrophic

Lei Zhao1, Xiaohai Ma, Hailong Ge

  • 1Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China, 100029.

European Radiology
|November 1, 2014
PubMed

Insights

Computed tomography (CT) accurately diagnoses coronary artery disease (CAD) in hypertrophic cardiomyopathy (HCM) patients. This cardiac CT protocol assesses coronary stenosis, LV function, and myocardial tissue characteristics.

Area of Science:

  • Cardiovascular Imaging
  • Radiology
  • Cardiology

Background:

  • Hypertrophic cardiomyopathy (HCM) can coexist with coronary artery disease (CAD).
  • Accurate diagnosis of both conditions is crucial for patient management.

Purpose of the Study:

  • To evaluate the diagnostic performance of cardiac computed tomography (CT) in patients with HCM and suspected CAD.
  • To assess CT's ability to evaluate coronary arteries and myocardial characteristics.

Main Methods:

  • Sixty patients with HCM and suspected CAD underwent cardiac CT, including CT coronary angiography (CTCA) and delayed enhancement CT.
  • CT findings were compared with catheter-based coronary angiography (CA).
  • Left ventricle (LV) wall thickness, function, and myocardial delayed enhancement (MDE) were assessed using both CT and cardiac magnetic resonance (CMR).

Main Results:

  • CTCA demonstrated high diagnostic accuracy for coronary arteries: 100% sensitivity, 94.4% specificity.
  • CT-assessed LV wall thickness and function correlated significantly with CMR (P < 0.01).
  • CT-determined focal myocardial delayed enhancement (MDE) volume was comparable to CMR.

Conclusions:

  • A comprehensive cardiac CT protocol is effective for diagnosing CAD in HCM patients.
  • CT provides valuable information on LV morphology, function, and tissue characterization in HCM.
  • This CT approach aids in ruling out coronary stenosis in this patient cohort.
Abstract

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