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Correlation between calcium and phosphorus in cord blood and birth size in term infants

Ayfer Colak1, Omur Yildiz, Burak Toprak

  • 1Department of Clinical Biochemistry, Tepecik Teaching and Research Hospital, Izmir, Turkey - beiot@hotmail.com.

Minerva Pediatrica
|November 1, 2014
PubMed

Insights

Cord blood calcium and phosphorus levels are linked to infant birth size. Higher levels of these minerals in newborns are associated with larger birth weight, length, and head circumference.

Area of Science:

  • Perinatal Medicine
  • Neonatal Physiology
  • Biochemistry

Background:

  • Calcium supplementation during pregnancy is hypothesized to influence fetal growth.
  • The relationship between cord blood mineral levels and neonatal anthropometrics requires further investigation.

Purpose of the Study:

  • To examine the association between cord blood calcium and phosphorus levels and birth size parameters in term infants.
  • To explore potential interactions between calcium and phosphorus in fetal growth.

Main Methods:

  • A cohort of 70 pregnant women and their neonates were studied.
  • Birth weight, length, and head circumference were measured.
  • Cord blood samples were analyzed for calcium, phosphorus, and parathyroid hormone levels, with associations assessed using Pearson correlation.

Main Results:

  • Cord blood calcium showed significant positive correlations with birth weight, length, and head circumference.
  • Cord blood phosphorus was positively correlated with birth length.
  • In infants with higher phosphorus levels, the correlation between cord blood calcium and birth size parameters was stronger.

Conclusions:

  • Cord blood levels of calcium and phosphorus are significantly associated with neonatal birth size.
  • Evidence suggests potential synergistic interactions between calcium and phosphorus in influencing fetal development.
Abstract

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