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Updated: Apr 21, 2026

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
Published on: December 27, 2013
Maytansine-loaded star-shaped folate-core PLA-TPGS nanoparticles enhancing anticancer activity
Xiaolong Tang1, Hong Dai2, Yongxiang Zhu1
1Stem cell Engineering Research Center, School of Medicine, Anhui University of Science and Technology Huainan 232001, P.R. China ; The State Key Laboratory of Virology, Life Sciences College, Wuhan University Wuhan, Hubei 430072, P.R. China.
Abstract:
The efficient delivery of therapeutic molecule agents into target cells of interest is a critical challenge to broad application of non-viral vector systems. In this research, maytansine-loaded star-shaped folate-core polylactide-D-α-tocopheryl polyethylene glycol 1000 succinate (FA-PLA-TPGS) block copolymer was applied to be a vector of maytansine for folate receptor positive (FR(+)) breast cancer therapy. The uptake of maytansine nanoparticles by SKBR3 cells were observed by fluorescence microscopy and confocal laser scanning microscopy. The cell viability of maytansine-NPs in SKBR3 cells was assessed according to the changed level of intracellular microtubules and apoptosis-associated proteins. The cytotoxicity of the SKBR3 cells was significantly increased by maytansine-NPs when compared with control groups. In conclusion, the maytansine-NPs offer a considerable potential formulation for FR-expressing tumor targeting biotherapy.
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